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Upper Gastrointestinal Cancer

Pharmacotherapy Overview in Gastroesophageal Cancers


Fluoropyrimidines are the backbone of many chemotherapy regimens for the management of esophagogastric cancer. 5-Fluorouracil (5-FU) and its oral form, capecitabine, can be used interchangeably and as monotherapy or in combination with other chemotherapy agents to treat both early and advanced diseases.

20/06/2023

Esophageal Cancer: symptoms, staging and treatment


Esophageal cancer is the seventh most common cancer among men and the 13th most common cancer among women, making it the eighth most commonly diagnosed cancer worldwide

26/10/2022

Gastric Adenocarcinoma


Gastric cancer is the third-leading cause of cancer-related deaths worldwide, accounting for approximately 1 in 12 of all oncologic deaths (Rawla; Global Cancer Observatory). In 2018, there were an estimated 783,000 gastric cancer deaths, just behind those reported for lung and liver cancer deaths. Gastric cancer is the fifth-most common cancer worldwide with over one million new cases annually. East Asia has the highest incidence of gastric cancer. Overall, the incidence and number of deaths attributable to gastric cancer has risen over the past 2-3 decades (GBD stomach).

24/10/2022

Pancreatic Cancer


There will be approximately 57,600 new pancreatic cancer diagnoses in the United States in 2020. While the incidence has been stable over the last decade in the United States at a rate of 12.3-12.8 cases per 100,000 persons, worldwide, the incidence of pancreatic cancer has risen 2.3-fold since 1990, resulting in 400,000 deaths in 2017 alone

19/10/2022

Current Diagnostics and Treatments for Pancreatic Neuroendocrine Tumors


Pancreatic neuroendocrine tumors (PNETs) arise from endocrine cells, sometimes referred to as islet cells, within the pancreas. The hormone producing islet cells cluster into small groups, known as islets of Langerhans, or simply islets, throughout the pancreas

17/10/2022

Intrahepatic Cholangiocarcinoma


Cholangiocarcinomas (CCA) are a heterogenous group of rare malignancies that arise from the biliary tract epithelium. CCA subtypes, which include intrahepatic cholangiocarcinoma (iCCA), perihilar cholangiocarcinoma (pCCA), and distal cholangiocarcinoma (dCCA), have distinct anatomic, biologic, and molecular characteristics. iCCAs arise proximal to the second order bile ducts

14/10/2022

The Diagnosis and Management of Gallbladder Cancer


Gallbladder cancer is a rare disease with a poor prognosis. The overall 5-year survival rate is 19%, ranging from 65% for localized cancers to 28% for regional and less than 2% for distant or metastatic disease

13/10/2022